Glutamate is an essential excitatory neurotransmitter for a number of for physiological, cognitive, and neural processes. As the major “activation” neurotransmitter within the brain, Glutamate and its “deactivation” counterpart, GABA, make up a whopping 90 percent of all neurotransmission signals within the brain.
- Along with its “little sister” Aspartate, Glutamate diffuses across exclusive excitatory pathways along the synaptic cleft where it binds with AMPA, NMDA, and metabotropic glutamate receptor channels 
- As a neurochemical, Glutamate plays a highly influential role in our learning and memory capacities , by aiding in long-term potentiation connectivity between neurons  and helping to encode newly learned stimuli in our memory circuits 
1. Lu, Y., Jia, Z., Janus, C., Henderson, J. T., Gerlai, R., Wojtowicz, J. M., et al. (1997). Mice lacking metabotropic glutamate receptor 5 show impaired learning and reduced CA1 long-term potentiation (LTP) but normal CA3 LTP. The Journal of Neuroscience, 17(13), 5196-5205.
2. Packard, M. G. (1999). Glutamate infused posttraining into the hippocampus or caudate-putamen differentially strengthens place and response learning. Proceedings of the National Academy of Sciences, 96(22), 12881-12886.
3. Bliss, T. V., & Collingridge, G. L. (1993). A synaptic model of memory: long-term potentiation in the hippocampus. Nature, 361(6407), 31-39.
4. Riedel, G. (1996). Function of metabotropic glutamate receptors in learning and memory. Trends in neurosciences, 19(6), 219-223.