GABA Gamma-aminobutyric acid, commonly known as GABA, serves as our nervous systems’ major inhibitory neurotransmitter for a wide range of neural, cognitive, and physiological processes. GABAergic reception is broken down into three major receptor subgroups – GABAa, GABAb, and GABAc.
- GABAa receptors primarily utilize GABA for biological processes related to sleep induction, working as a mediator for melatonin activity while also helping to attenuate brain waves to match the circadian rhythm .
- GABAb reception is believed to be involved in both wakeful cognitive processes as well as initiating the onset of the rapid-eye-movement sleep stage .
- GABAc receptors are similar to GABAb, with a major difference being that they exclusively incentivize wakeful cognition- a feature that has linked to this GABA receptor subgroup to select treatments for non-clinical sleep difficulty.
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