While Magnesium L-Threonate’s superior bioavailability has distinguished it apart from other magnesium sources, it’s reported effects on learning and memory have firmly established its locus within magnesium supplement research. Acting on the hippocampus, Magnesium L-Threonate is suggested to upregulate both short-term synaptic facilitation and long-term potentiation of memory acquisition by increasing activity at the glutamate NR2B subunits, NMDAR signaling, and synaptic plasticity. A number of recent studies assessing cognitive impairment reversal in mice models have also identified Magnesium L-Threonate as a potential neuroprotective agent against synaptic loss and cognitive deficits.,
On the other end of the blood brain barrier, Mg2+ serves as an essential dietary mineral and is crucial in regulating bodily functions. It is a key element in maintaining healthy bones, blood vessels, nerves, and muscles. Furthermore, high magnesium intake is associated with greater bone density., There is a growing concern regarding widespread magnesium deficiencies in industrialized nations because these diets are generally deficient in significant magnesium food sources.
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