Uridine is one of the five standard nucleosides which make up nucleic acids, the others are adenosine, thymidine, cytidine, and guanosine . It is a pyrimidine nucleoside that is crucial in the synthesis of RNA and cellular membranes, as well as the regulation of normal physiological processes. Some food sources that contain Uridine are beer, broccoli, brewer’s yeast, tomatoes, sugar cane extract, and liver.
As a supplement, Uridine is reported to help facilitate learning by increasing the synthesis of neural RNA responsible for creating and strengthen neural connections in the brain . Considering that RNA levels decrease as we age, Uridine has been popularly referred to as an “anti-aging” aid for the brain. Further, Uridine also promotes the synthesis of phosphatides in the brain, which directly increases the number of available synaptic proteins important for our learning capacity . Supplementation of Uridine with DHA may synergistically enhance nootropic effect and they have become a common pair among nootropic users .
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2. Wang, L., Pooler, A. M., Albrecht, M. A., & Wurtman, R. J. (2005). Dietary uridine-5′-monophosphate supplementation increases potassium-evoked dopamine release and promotes neurite outgrowth in aged rats. Journal of molecular neuroscience, 27(1), 137-145.
3. Holguin, S., Martinez, J., Chow, C., & Wurtman, R. (2008). Dietary uridine enhances the improvement in learning and memory produced by administering DHA to gerbils. The FASEB Journal, 22(11), 3938-3946.
4. Yamamoto, T., Moriwaki, Y., Takahashi, S., Tsutsumi, Z., Ka, T., Fukuchi, M., et al. (2002).Effect of beer on the plasma concentrations of uridine and purine bases.Metabolism,51(10), 1317-1323.