First synthesized in 1978, Aniracetam is considered to be a far more potent form of its predecessor, Piracetam, due to its superior bioavailability . Aniracetam is fat-soluble, meaning it crosses the blood-brain barrier with relative ease and absorbs most efficiently when consumed with a fatty food source. Like Aniracetam is thought to increase focus capacity by desensitizing hippocampal AMPA-glutamate receptors– enhancing the effectiveness of glutamate neurotransmission . Considered a cholinergic compound, Aniracetam’s benefits to daily cognition are also suggested to function through its upregulation of acetylcholine production and release . While Aniracetam is understood to be quite potent in its effects, it also possessive a relatively short half-life compared to Piracetam, meaning that its effects are shorter lived.
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