Considered significantly more potent that its synthetic predecessor Piracetam, Oxiracetam was the third compound to developed in the to the “Racetam” lineage . While its major chemical divergence from Piracetam is the addition of a single hydroxyl group, Oxiracetam acts through a similar set of mechanisms, increasing neurotransmitter activity by enhancing the AMPA-subset of glutamate receptors . Research suggests that this primary mechanism– combined with Oxiracetam’s indirect upregulation of acetylcholine– are likely responsible for Oxiracetam’s benefit potential to focus, memory recall, learning, sensory perception, and neuroplasticity . In 1964, Romanian scientist Corneliu E. Giurgea synthesized Piracetam, the first of an entire class of Nootropics called the “Racetams” . Since then, multiple derivatives of Piracetam have been synthesized, Oxiracetam was the third Racetam to be synthesized and is still one of the most powerful . In addition to Oxiracetam, other popular Racetams include Piracetam, Aniracetam, Pramiracetam, and Phenylpiracetam. Although they are all part of the same family of Nootropics, different Racetams appear to have differing effects, anecdotally.
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